![]() ![]() The Akt, p62 and MuRF expressions and mobility assessment showed no significance. Myogenin expression levels were decreased in the PIL + VD group compared with the CO group. MyoD expression was higher in PIL mice compared to PIL + VD, while myostatin expression was higher in PIL + VD than PIL group. LC3-II expression was higher in PIL compared to CO and PIL + VD groups. PIL mice showed similar myofiber CSA compared to CO and PIL + VD groups. The PIL + VD group showed lower muscle strength compared to the CO and PIL groups at different time points. The tibialis anterior and gastrocnemius muscles were collected to evaluate myofiber cross-sectional area (CSA) and protein expression. Physical function was evaluated on days 0, 60, 120 and 180. Methodsīalb/c mice with lupus-like disease induced by pristane injection were randomized into three groups: pristane-induced lupus (PIL n = 10), pristane-induced lupus + vitamin D supplementation (PIL + VD n = 10) and healthy controls (CO n = 8). Because of the poor understanding of signaling pathways involved in SLE muscle wasting, the aim of this study was to evaluate the effects of vitamin D supplementation on skeletal muscle in mice with pristane-induced lupus. Clinical evidence of skeletal muscle involvement is not uncommon in systemic lupus erythematosus (SLE).
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